Engineer Position in Evolution of Centromere and Genome Organisation (M/F)

L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est constitué d'un hôpital et d'un Centre de recherche de plus de 1000 collaborateurs avec une forte représentativité internationale.

L’objectif du Centre de recherche de l’institut Curie est de développer la recherche fondamentale et d’utiliser les connaissances produites pour améliorer le diagnostic, le pronostic, la thérapeutique des cancers dans le cadre du continuum entre la recherche fondamentale et l’innovation au service du malade.

Laboratory

The successful candidate will join Ines Drinnenberg's team affiliated to the “Nuclear Dynamics” Unit at Institut Curie.

The Institut Curie is a highly vibrant research center, offering an international and multidisciplinary research environment in central Paris, and offers access to state-of-the-art facilities.

Centromeres and kinetochores are essential for cell division across eukaryotes, yet their organisation and composition varies among species. The host lab studies this evolutionary diversity using lepidoptera as model system that lack the otherwise essential centromeric marker protein CENP-A. Using this model the team recently identified a new mechanism of centromere specification in these species. Furthermore, using proteomic and remote homology predictions the team has uncovered a diversity of kinetochore components despite the absence of CENP-A.

The project

The candidate will investigate the composition and connectivity of the lepidopteran kinetochore complexes using proteomic analyses and investigate the evolution of centromere and genome organisation across holocentric insects using genomic approaches. For this the candidates will also benefit from the state-of-the-art technological platforms at Curie to accomplish her/his work. 

Candidate Profile

Training and Skills required

-        Training: Candidates should hold at least a Master degree  

-        Scientific skills: We invite applications from candidates with a strong interest in chromosome biology, evolution and cellular biology

-        Language skills: Candidates should be fluent in English, which is the language used in the lab.

Abilities

-        Highly self-motivated

-        Rigourous

-        Creativity, ability to work independently and to collaborate with others

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract.

Starting date: position available immediately

Duration: six months, renewable

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Reference:

Contact

Please send your CV, letter of motivation and 2 references, to …

Publication date: 25/06/2025

Deadline for application: until filled

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf